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KMID : 1009020150130020168
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Clinical Psychopharmacology and Neuroscience
2015 Volume.13 No. 2 p.168 ~ p.173
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The Effect of Choline Acetyltransferase Genotype on Donepezil Treatment Response in Patients with Alzheimer’s Disease
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Lee Kang-Uk
Lee Jung-Hie
Lee Dong-Young
Youn Jong-Chul
Kim Jeong-Lan
Moon Seok-Woo
Kim Bong-Jo
Ryu Seung-Ho
Kim Moon-Doo
Lee Chang-Uk
Lee Nam-Jin
Chang Sung-Man
Kim Young-Hoon
Kim Do-Hoon
Lee Hae-Kook
Woo Jong-Inn
Kim Ki-Woong
Jhoo Jin-Hyeong
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Abstract
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Objective : We examined the difference in responses to donepezil between carriers and non-carriers of the A allele at the +4 position of the choline acetyltransferase (ChAT) gene in Koreans.
Methods : Patients who met the criteria for probable Alzheimer’s disease (AD) (n=199) were recruited. Among these, 145 completed the 12-week follow-up evaluation and 135 completed the 26-week scheduled course. Differences and changes in the Korean version of the mini-mental state examination (MMSE-KC) score, Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Assessment Battery (CERAD-K[N]) wordlist subtest score (WSS), CERAD-K(N) total score (TS), and the Korean version of geriatric depression scale (GDS-K) score between baseline and 12 weeks or 26 weeks were assessed by the Student’s t-test.
Results : At 12 weeks, the changes in the MMSE-KC score, CERAD-K(N) WSS, and CERAD-K(N) TS from baseline were not significant between ChAT A allele carriers and non-carriers; however, at 26 weeks, these changes were significantly larger in ChAT A allele carriers than in non-carriers (p=0.02 for MMSE-KC and p=0.03 for CERAD-K(N) WSS respectively).
Conclusion : Our findings in this study suggested that presence of the A allele at the +4 position of ChAT might positively influence the treatment effect of donepezil in the early stages of AD in Koreans.
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KEYWORD
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Choline acetyltransferase, Single nucleotide polymorphism, Alzheimer disease, Donepezil
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